Cell Cycle, Mitosis & Meiosis
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Question No. 1 Marks +1 -0 Time
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Which of the following events primarily occurs during the S phase of the eukaryotic cell cycle?

A. Cell growth and organelle duplication
B. DNA replication
C. Chromosome condensation
D. Spindle fiber formation
Question No. 2 Marks +1 -0 Time
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During which stage of meiosis I do homologous chromosomes separate and move to opposite poles of the cell?

A. Prophase I
B. Metaphase I
C. Anaphase I
D. Telophase I
Question No. 3 Marks +1 -0 Time
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Which of the following statements about G0 phase is correct?

A. Cells in G0 are actively dividing.
B. It is a temporary resting phase for cells that have stopped dividing.
C. DNA replication occurs during G0.
D. Cells exit G0 to immediately enter M phase.
Question No. 4 Marks +1 -0 Time
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Consider the following pairs relating to cell division:

1. Synapsis – Alignment of sister chromatids
2. Chiasmata – Site of crossing over
3. Centromere – Connects homologous chromosomes

How many of the above pairs are correctly matched?
Question No. 5 Marks +1 -0 Time
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Which of the following is a key difference between mitosis and meiosis?

A. Mitosis produces four haploid cells, while meiosis produces two diploid cells.
B. Mitosis involves two rounds of nuclear division, while meiosis involves one.
C. Crossing over occurs in meiosis but not typically in mitosis.
D. Sister chromatids separate in meiosis I, while homologous chromosomes separate in mitosis.
Question No. 6 Marks +1 -0 Time
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What is the primary function of cyclin-dependent kinases (CDKs) in cell cycle regulation?

A. They directly synthesize DNA during the S phase.
B. They act as transcription factors for cell cycle genes.
C. They phosphorylate target proteins when activated by cyclins.
D. They degrade cyclins to halt cell cycle progression.
Question No. 7 Marks +1 -0 Time
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Which of the following events marks the beginning of Anaphase in mitosis?

A. Alignment of chromosomes at the metaphase plate.
B. Condensation of chromatin into visible chromosomes.
C. Splitting of the centromere and separation of sister chromatids.
D. Disappearance of the nuclear envelope.
Question No. 8 Marks +1 -0 Time
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A diploid organism has 2n=10 chromosomes. How many chromatids will be present in a cell at Metaphase I of meiosis?

A. 5
B. 10
C. 20
D. 40
Question No. 9 Marks +1 -0 Time
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The process of cytokinesis in animal cells involves the formation of a:

A. Cell plate
B. Phragmoplast
C. Cleavage furrow
D. Cell wall
Question No. 10 Marks +1 -0 Time
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Which phase of meiosis II is essentially identical to mitotic anaphase?

A. Prophase II
B. Metaphase II
C. Anaphase II
D. Telophase II
Question No. 11 Marks +1 -0 Time
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Match the following events with their respective stages of the cell cycle:

Column I (Event)Column II (Stage)
1. Growth and preparation for DNA synthesisP. M phase
2. Separation of sister chromatidsQ. G1 phase
3. Formation of bivalentsR. Anaphase (Mitosis)
4. Karyokinesis and cytokinesisS. Prophase I (Meiosis)

Choose the correct combination:
Question No. 12 Marks +1 -0 Time
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What is the significance of the reductional division in meiosis?

A. It ensures that daughter cells receive an identical set of chromosomes.
B. It reduces the chromosome number by half, leading to haploid gametes.
C. It results in the formation of somatic cells for growth and repair.
D. It allows for the repair of damaged DNA before cell division.
Question No. 13 Marks +1 -0 Time
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A cell contains 46 chromosomes at the beginning of mitosis. How many chromosomes will be present in each daughter cell at the end of mitosis?

A. 23
B. 46
C. 92
D. Varies depending on cell type
Question No. 14 Marks +1 -0 Time
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Which checkpoint primarily ensures that all chromosomes are properly attached to the spindle fibers before anaphase begins?

A. G1 checkpoint
B. S checkpoint
C. G2 checkpoint
D. M checkpoint (Spindle checkpoint)
Question No. 15 Marks +1 -0 Time
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The phenomenon of crossing over results in:

A. Reduction of chromosome number
B. Production of genetically identical daughter cells
C. Genetic recombination and increased genetic diversity
D. Separation of homologous chromosomes
Question No. 16 Marks +1 -0 Time
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Which stage of mitosis is characterized by the breakdown of the nuclear envelope and the migration of centrosomes to opposite poles?

A. Metaphase
B. Anaphase
C. Prophase
D. Telophase
Question No. 17 Marks +1 -0 Time
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Consider the following events associated with meiosis:

1. Synapsis of homologous chromosomes
2. Separation of sister chromatids
3. Formation of chiasmata
4. Alignment of homologous pairs at the metaphase plate

Which of these events occur exclusively during Meiosis I and not Meiosis II or Mitosis?
Question No. 18 Marks +1 -0 Time
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What is the main purpose of mitosis in multicellular organisms?

A. To produce gametes for sexual reproduction.
B. To reduce the chromosome number by half.
C. For growth, repair, and asexual reproduction.
D. To increase genetic diversity within the population.
Question No. 19 Marks +1 -0 Time
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The term 'bivalent' (or tetrad) refers to:

A. Two sister chromatids joined at a centromere.
B. A pair of homologous chromosomes aligned side-by-side during meiosis I.
C. A single chromosome composed of two DNA molecules.
D. Any two non-homologous chromosomes found in a diploid cell.
Question No. 20 Marks +1 -0 Time
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Which of the following is responsible for initiating the separation of sister chromatids during anaphase?

A. Cyclin B
B. CDK1
C. Separase
D. Cohesin
Question No. 21 Marks +1 -0 Time
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If a cell fails to pass the G2 checkpoint, which of the following is most likely to occur?

A. The cell will immediately undergo apoptosis.
B. The cell will proceed to S phase without replicating DNA.
C. The cell will arrest the cycle to repair DNA or await completion of DNA replication.
D. The cell will enter mitosis with damaged DNA.
Question No. 22 Marks +1 -0 Time
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Which of the following contributes to genetic variation in sexually reproducing organisms?

1. Crossing over during Prophase I
2. Independent assortment of homologous chromosomes during Metaphase I
3. Random fertilization

A. 1 and 2 only
B. 1 and 3 only
C. 2 and 3 only
D. 1, 2, and 3
Question No. 23 Marks +1 -0 Time
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In which stage of the cell cycle is the cell committed to divide, assuming conditions are favorable and there is no DNA damage?

A. G0 phase
B. G1 phase (after passing the R point/Restriction point)
C. S phase
D. G2 phase
Question No. 24 Marks +1 -0 Time
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Which of the following accurately describes the chromosome number and DNA content (C value) changes during Meiosis I for a diploid cell (2n, 2C) before S phase?

A. From 2n, 4C to n, 2C
B. From 2n, 2C to n, 1C
C. From n, 2C to n, 1C
D. From 2n, 4C to 2n, 2C
Question No. 25 Marks +1 -0 Time
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The primary role of the Anaphase Promoting Complex/Cyclosome (APC/C) is to:

A. Synthesize new cyclins for the next cell cycle phase.
B. Activate CDKs to promote entry into mitosis.
C. Target specific proteins for degradation, including cyclins and securin.
D. Repair damaged DNA at cell cycle checkpoints.

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